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KMID : 0364219770200010041
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Korean Journal of Zoology
1977 Volume.20 No. 1 p.41 ~ p.48
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DNA Repair Synthesis Induced by Bleomycin in HeLa S3 Cells Pretreated with Base Analogs
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Um Kyung-Il
Park Sang-Dai
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Abstract
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Dose response of DNA repair synthesis induced by bleomycin was dose-dependent in lower doses, and maximum rate of it at 5 $\\mu$g/ml represents about 15% of total cells analyzed. At higher doses DNA-repair synthesis was reduced and the rate of it remained unchanged even prolonged treatment. Pretreatment with BUdR or IUdR was found to enhance DNA repair synthesis and also to interfere with semiconservative DNA synthesis at higher doses. Time dependence study showed that DNA repair synthesis occurred as long as for 24 hours after removal of bleomycin. These results seem to suggest that bleomycin is not to be an effective chemical in inducing excision repair and that damages induced in DNA by this drug might include not only strand breaks but other types of DNA damage.
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